Prostate cancer is the most common cancer in men. In 2014 (the most recent year for which numbers are available) 172,258 men in the U.S. were diagnosed with prostate cancer and 28,343 men in the U.S. died from prostate cancer (Centers for Disease Control and Prevention, 2018). Medigen is using the advanced RNA VLP [...]
Dengue and Zika viruses are mosquito-borne flaviviruses related to Japanese encephalitis and yellow fever viruses. Estimates indicate ~400 million of dengue infections per year, of which ~100 million show clinical signs. Approximately 3.9 billion people in 128 countries are at risk of infection. There are 4 distinct serotypes of the virus. Recovery from infection [...]
Yellow fever (YF) causes an acute hemorrhagic fever disease in tropical Africa and Latin America. The YF vaccine YF17D is available and is prepared in eggs. Shortages of the YF17D vaccine and rare adverse effects have been reported. To develop a novel YF vaccine, Medigen applied iDNA technology. The iDNA represents genetically stable DNA [...]
Japanese encephalitis virus (JEV) is the main cause of viral encephalitis in many countries of Asia with an estimated 68,000 clinical cases every year and more than 3 billion people at risks of infection. Medigen uses iDNA technology encoding synthetic, live-attenuated JEV vaccine. JEV iDNA can be used either directly for vaccination, or for [...]
Lassa fever is a hemorrhagic fever caused by the Lassa virus that commonly spreads to humans in Africa from the rodent Mastomys natalensis. Symptoms include fever, weakness, headaches, muscle pain and bleeding from the mouth or gastrointestinal tract. Once infected, the risk of death is about 1% and frequently occurs within two weeks of [...]
There are 18 different hemagglutinin (H) subtypes and 11 different neuraminidase (N) subtypes of influenza A virus, as well as two lineages of influenza B virus. Annual influenza epidemics are often caused by H1 and H3 subtypes. In addition, H5, H7, H9 and H10 subtypes represent a global health concern. People do not have [...]
Chikungunya virus (CHIKV) causes chikungunya fever, a global infectious disease. The virus is found worldwide including Europe and the U.S. CHIKV is transmitted to people usually by two mosquito species, Aedes aegypti and Aedes albopictus. Symptoms include arthralgia, respiratory failure, cardiovascular disease, hepatitis, and central nervous system problems, especially in the elderly and children. [...]
Venezuelan equine encephalitis (VEE) virus causes outbreaks in the North, Central, and South America and has spread to the southern U.S. in the past, including an outbreak in Texas in 1971. Climate, ecological changes and international travel have increased the risk of VEEV re-emergence. Currently there is no approved vaccine or specific treatment for [...]
